anti- AMPK beta 1 antibody

Product Description

anti- AMPK beta 1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase (AMPK). AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase (ACC) and beta-hydroxy beta-methylglutaryl-CoA reductase (HMGCR), key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit may be a positive regulator of AMPK activity. The myristoylation and phosphorylation of this subunit have been shown to affect the enzyme activity and cellular localization of AMPK. This subunit may also serve as an adaptor molecule mediating the association of the AMPK complex..

Immunogen: protein kinase, AMP-activated, beta 1 non-catalytic subunit

Synonyms: AMPK, AMPK beta 1, AMPK subunit beta 1, AMPKb, HAMPKb, PRKAB1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200

Image 1: Immunohistochemistry of paraffin-embedded rat kidney using FNab00377(PRKAB1 antibody) at dilution of 1:100

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Image 4: mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab00377( PRKAB1 Antibody) at dilution of 1:1000

Gene ID: 5564

Research Area: Metabolism

Uniprot ID: Q9Y478