anti- APOBEC3C antibody

Product Description

anti- APOBEC3C antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: DNA deaminase(cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and-independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single-or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus(SIV), hepatitis B virus(HBV), herpes simplex virus 1(HHV-1) and Epstein-Barr virus(EBV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation..

Immunogen: apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3C

Synonyms: APOBEC1L, PBI

Reactivity: Human

Tested Application: ELISA, IHC, WB

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human ovary tumor tissue slide using FNab00494(APOBEC3C Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

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Image 4: Human peripheral blood leukocyte cells were subjected to SDS PAGE followed by western blot with FNab00494(APOBEC3C Antibody) at dilution of 1:1000

Gene ID: 27350

Research Area: Metabolism

Uniprot ID: Q9NRW3