Product Description
anti- APP antibody is available at Gentaur for Next week Delivery.
Purification: Protein A+G purification
Background: Beta-amyloid peptides are lipophilic metal chelators with metal-reducing activity. Bind transient metals such as copper, zinc and iron. In vitro, can reduce Cu(2+) and Fe(3+) to Cu(+) and Fe(2+), respectively. Beta-amyloid 42 is a more effective reductant than beta-amyloid 40. Beta-amyloid peptides bind to lipoproteins and apolipoproteins E and J in the CSF and to HDL particles in plasma, inhibiting metal-catalyzed oxidation of lipoproteins. Beta-APP42 may activate mononuclear phagocytes in the brain and elicit inflammatory responses. Promotes both tau aggregation and TPK II-mediated phosphorylation. Interaction with overexpressed HADH2 leads to oxidative stress and neurotoxicity. Also binds GPC1 in lipid rafts. The gamma-CTF peptides as well as the caspase-cleaved peptides, including C31, are potent enhancers of neuronal apoptosis. .
Immunogen: amyloid beta A4 precursor protein
Synonyms: A4, ABPP,Alzheimer disease amyloid protein,Cerebral vascular amyloid peptide,Beta-amyloid precursor protein, CVAP,PreA4
Reactivity: Human, Pig
Tested Application: ELISA, WB, IHC
Recommended dilution: WB: 1:500-1:2000; IHC: 1:50-1:500
Image 1: Immunohistochemistry of paraffin-embedded human gliomas tissue slide using FNab00513(APP Antibody) at dilution of 1:200
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Image 4: HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab00513(APP Antibody) at dilution of 1:1000
Gene ID: 351
Research Area: Metabolism
Uniprot ID: P05067