anti- ATR antibody

Product Description

anti- ATR antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation(IR), ultraviolet light(UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates BRCA1, CHEK1, MCM2, RAD17, RPA2, SMC1 and p53/TP53, which collectively inhibit DNA replication and mitosis and promote DNA repair, recombination and apoptosis. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX at sites of DNA damage, thereby regulating DNA damage response mechanism. Required for FANCD2 ubiquitination. Critical for maintenance of fragile site stability and efficient regulation of centrosome duplication..

Immunogen: ataxia telangiectasia and Rad3 related

Synonyms: ATR, FRAP related protein 1, FRP1, MEC1, SCKL, SCKL1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:300-1:1000; IP: 1:200-1:1000; IHC: 1:50-1:500; IF: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded mouse testis tissue slide using FNab00736 (ATR antibody) at dilution of 1:200

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab00736(ATR antibody) at dilution of 1:500

Gene ID: 545

Research Area: Metabolism

Uniprot ID: Q13535