anti- BAP1 antibody

Product Description

anti- BAP1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1. Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119'(H2AK119ub1). Does not deubiquitinate monoubiquitinated histone H2B. Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains. Deubiquitination of HCFC1 does not lead to increase stability of HCFC1. Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination. It however does not mediate deubiquitination of BRCA1 and BARD1. Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal(NLS), thereby protecting it from cytoplasmic sequestration(PubMed:24703950). Acts as a tumor suppressor..

Immunogen: BRCA1 associated protein-1(ubiquitin carboxy-terminal hydrolase)

Synonyms: BAP1, BRCA1 associated protein 1, Cerebral protein 6, HUCEP 13, hucep 6, KIAA0272, UCHL2

Reactivity: Human, Mouse

Tested Application: ELISA, WB

Recommended dilution: WB: 1:500-1:1000

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Image 4: A2780 cells were subjected to SDS PAGE followed by western blot with FNab00800(BAP1 antibody) at dilution of 1:300

Gene ID: 8314

Research Area: Metabolism

Uniprot ID: Q92560