anti- BRD8 antibody

Product Description

anti- BRD8 antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: May act as a coactivator during transcriptional activation by hormone-activated nuclear receptors(NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase(HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome-DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. Component of a SWR1-like complex that specifically mediates the removal of histone H2A.Z/H2AFZ from the nucleosome..

Immunogen: bromodomain containing 8

Synonyms: SMAP, SMAP2

Reactivity: Human

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500-1:2000; IHC: 1:50-1:500; IF: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab00950( BRD8 Antibody) at dilution of 1:200

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Image 4: fetal human brain tissue were subjected to SDS PAGE followed by western blot with FNab00950( BRD8 Antibody) at dilution of 1:1000

Gene ID: 10902

Research Area: Metabolism

Uniprot ID: Q9H0E9