anti- BRSK2 antibody

Product Description

anti- BRSK2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Serine/threonine-protein kinase that plays a key role in polarization of neurons and axonogenesis, cell cycle progress and insulin secretion. Phosphorylates CDK16, CDC25C, MAPT/TAU, PAK1 and WEE1. Following phosphorylation and activation by STK11/LKB1, acts as a key regulator of polarization of cortical neurons, probably by mediating phosphorylation of microtubule-associated proteins such as MAPT/TAU at 'Thr-529' and 'Ser-579'. Also regulates neuron polarization by mediating phosphorylation of WEE1 at 'Ser-642' in postmitotic neurons, leading to down-regulate WEE1 activity in polarized neurons. Plays a role in the regulation of the mitotic cell cycle progress and the onset of mitosis. Plays a role in the regulation of insulin secretion in response to elevated glucose levels, probably via phosphorylation of CDK16 and PAK1. While BRSK2 phosphorylated at Thr-174 can inhibit insulin secretion(PubMed:22798068), BRSK2 phosphorylated at Thr-260 can promote insulin secretion(PubMed:22669945). Regulates reorganization of the actin cytoskeleton. May play a role in the apoptotic response triggered by endoplasmatic reticulum(ER) stress..

Immunogen: BR serine/threonine kinase 2

Synonyms: C11orf7, PEN11B, SADA, STK29

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human prostate cancer using FNab00966(BRSK2 antibody) at dilution of 1:50

Image 2: .

Image 3:

Image 4: mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab00966(BRSK2 antibody) at dilution of 1:500

Gene ID: 9024

Research Area: Metabolism

Uniprot ID: Q8IWQ3