anti- CD146/MCAM antibody

Product Description

anti- CD146/MCAM antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: CD146, also known as melanoma cell adhesion molecule(MCAM) or MUC18, originally identified as a biomarker of melanoma progression, is a transmembrane glycoprotein belonging to the immunoglobulin(Ig) superfamily(PMID: 8378324). Structurally, it consists of five Ig domains, a transmembrane domain, and a cytoplasmic region. In normal adult tissue, CD146 is primarily expressed by vascular endothelium and smooth muscle. CD146 is a key cell adhesion protein in vascular endothelial cell activity and angiogenesis, and has been used as marker of circulating endothelium cells(CECs)(PMID: 19356677)..

Immunogen: melanoma cell adhesion molecule

Synonyms: CD146, MCAM, MUC18,Cell surface glycoprotein MUC18,Cell surface glycoprotein P1H12,Melanoma cell adhesion molecule,Melanoma-associated antigen A32,Melanoma-associated antigen MUC18

Reactivity: Human

Tested Application: ELISA, WB, IHC, FC

Recommended dilution: WB: 1:500-1:5000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human liver cancer tissue slide using FNab01429(CD146, MCAM Antibody) at dilution of 1:20

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Image 4: A375 cells were subjected to SDS PAGE followed by western blot with FNab01429(CD146, MCAM antibody) at dilution of 1:1000

Gene ID:

Research Area: Metabolism

Uniprot ID: P43121