anti- CDK8 antibody

Product Description

anti- CDK8 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Phosphorylates the CTD(C-terminal domain) of the large subunit of RNA polymerase II(RNAp II), which may inhibit the formation of a transcription initiation complex. Phosphorylates CCNH leading to down-regulation of the TFIIH complex and transcriptional repression. Recruited through interaction with MAML1 to hyperphosphorylate the intracellular domain of NOTCH, leading to its degradation..

Immunogen: cyclin-dependent kinase 8

Synonyms:

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human stomach cancer using FNab01563(CDK8 antibody) at dilution of 1:50

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Image 4: NIH/3T3 cells were subjected to SDS PAGE followed by western blot with FNab01563(CDK8 antibody) at dilution of 1:500

Gene ID: 1024

Research Area: Metabolism

Uniprot ID: P49336