anti- CTCF antibody

Product Description

anti- CTCF antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: This gene is a member of the BORIS + CTCF gene family and encodes a transcriptional regulator protein with 11 highly conserved zinc finger (ZF) domains. This nuclear protein is able to use different combinations of the ZF domains to bind different DNA target sequences and proteins. Depending upon the context of the site, the protein can bind a histone acetyltransferase (HAT)-containing complex and function as a transcriptional activator or bind a histone deacetylase (HDAC)-containing complex and function as a transcriptional repressor. If the protein is bound to a transcriptional insulator element, it can block communication between enhancers and upstream promoters, thereby regulating imprinted expression. Mutations in this gene have been associated with invasive breast cancers, prostate cancers, and Wilms' tumors. Alternatively spliced transcript variants encoding different isoforms have been found for this gene..

Immunogen: CCCTC-binding factor (zinc finger protein)

Synonyms:

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution: WB: 1:1000 - 1:2000; IHC: 1:50 - 1:200; ChIP : 1:50 - 1:200

Image 1: Immunohistochemistry of paraffin-embedded mouse brain using FNab02049(CTCF antibody) at dilution of 1:100

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Image 4: human brain tissue were subjected to SDS PAGE followed by western blot with FNab02049(CTCF antibody) at dilution of 1:1000

Gene ID: 10664

Research Area: Metabolism

Uniprot ID: P49711