anti- CXCL12 antibody

Product Description

anti- CXCL12 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Chemoattractant active on T-lymphocytes, monocytes, but not neutrophils. Activates the C-X-C chemokine receptor CXCR4 to induce a rapid and transient rise in the level of intracellular calcium ions and chemotaxis. Also binds to atypical chemokine receptor ACKR3, which activates the beta-arrestin pathway and acts as a scavenger receptor for SDF-1. SDF-1-beta(3-72) and SDF-1-alpha(3-67) show a reduced chemotactic activity. Binding to cell surface proteoglycans seems to inhibit formation of SDF-1-alpha(3-67) and thus to preserve activity on local sites. Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation..

Immunogen: chemokine(C-X-C motif) ligand 12(stromal cell-derived factor 1)

Synonyms: SDF1, SDF1A, SDF1B

Reactivity: Human, Mouse

Tested Application: ELISA, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human liver cancer tissue using FNab02093(CXCL12 antibody) at dilution of 1:50

Image 2: .

Image 3:

Image 4:

Gene ID: 6387

Research Area: Metabolism

Uniprot ID: P48061