anti- DCUN1D1 antibody

Product Description

anti- DCUN1D1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Part of an E3 ubiquitin ligase complex for neddylation. Promotes neddylation of cullin components of E3 cullin-RING ubiquitin ligase complexes. Acts by binding to cullin-RBX1 complexes in the cytoplasm and promoting their nuclear translocation, enhancing recruitment of E2-NEDD8(UBE2M-NEDD8) thioester to the complex, and optimizing the orientation of proteins in the complex to allow efficient transfer of NEDD8 from the E2 to the cullin substrates(PubMed:25349211). Involved in the release of inhibitory effets of CAND1 on cullin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression(By similarity)..

Immunogen: DCN1, defective in cullin neddylation 1, domain containing 1(S. cerevisiae)

Synonyms: DCUN1L1, RP42, SCCRO

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IHC, WB

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human gliomas using FNab02278(DCUN1D1 antibody) at dilution of 1:50

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Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab02278(DCUN1D1 Antibody) at dilution of 1:3000

Gene ID: 54165

Research Area: Metabolism

Uniprot ID: Q96GG9