anti- DHX36 antibody

Product Description

anti- DHX36 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Proposed to have a global role in regulating mRNA expression including transcriptional regulation and mRNA stability. Binds with high affinity to and resolves tetramolecular RNA and DNA quadruplex structures. Unwinds intramolecular quadruplexes derived from the ZIC1 and the MYC promoters. Binds to quadruplex structures in the promoters of YY1 and ALPL genes and regulates their expression. Binds to telomerase RNA template component(TERC) 5'-end(nucleotides 1-43) and unwinds an internal quadruplex formation in TERC 5'-end to promote P1 helix formation; the P1 helix acts as a template boundary ensuring accurate reverse transcription and is disrupted by quadruplex formation. May be involved in regulation of telomere length. Plays a role in degradation and deadenylation of mRNAs containing in their 3'-UTR the consensus ARE sequence element. May function in sex development and spermatogenesis. May play a role in ossification..

Immunogen: DEAH(Asp-Glu-Ala-His) box polypeptide 36

Synonyms: DDX36, KIAA1488, MLEL1, RHAU

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human prostate using FNab02380(DHX36 antibody) at dilution of 1:50

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Image 4: human brain tissue were subjected to SDS PAGE followed by western blot with FNab02380(DHX36 antibody) at dilution of 1:800

Gene ID: 170506

Research Area: Metabolism

Uniprot ID: Q9H2U1