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Product Description
anti- DTX3L antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Ubiquitin ligase that mediates monoubiquitination of 'Lys-91' of histone H4(H4K91ub1), in response to DNA damage. Protects cells exposed to DNA-damaging agents. The exact role of H4K91ub1 in DNA damage response is still unclear but it may function as a licensing signal for additional histone H4 post-translational modifications such as H4 'Lys-20' methylation(H4K20me). Involved in the recruitment of 53BP1/TP53BP1 to sites of DNA damage by mediating H4K91ub1 formation. In concert with PARP9, plays a role in PARP1-dependent DNA damage repair. PARP1-dependent PARP9-DTX3L-mediated ubiquitination promotes the rapid and specific recruitment of 53BP1/TP53BP1, UIMC1/RAP80, and BRCA1 to DNA damage sites..
Immunogen: deltex 3-like(Drosophila)
Synonyms: BBAP
Reactivity: Human
Tested Application: ELISA, WB
Recommended dilution:
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Image 4: MCF-7 cells were subjected to SDS PAGE followed by western blot with FNab02556(DTX3L antibody) at dilution of 1:600
Gene ID: 151636
Research Area: Metabolism
Uniprot ID: Q8TDB6
