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Product Description
anti- E2F7 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Atypical E2F transcription factor that participates in various processes such as angiogenesis, polyploidization of specialized cells and DNA damage response. Mainly acts as a transcription repressor that binds DNA independently of DP proteins and specifically recognizes the E2 recognition site 5'-TTTC[CG]CGC-3'. Directly represses transcription of classical E2F transcription factors such as E2F1. Acts as a regulator of S-phase by recognizing and binding the E2-related site 5'-TTCCCGCC-3' and mediating repression of G1/S-regulated genes. Plays a key role in polyploidization of cells in placenta and liver by regulating the endocycle, probably by repressing genes promoting cytokinesis and antagonizing action of classical E2F proteins(E2F1, E2F2 and/or E2F3). Required for placental development by promoting polyploidization of trophoblast giant cells. Also involved in DNA damage response: up-regulated by p53/TP53 following genotoxic stress and acts as a downstream effector of p53/TP53-dependent repression by mediating repression of indirect p53/TP53 target genes involved in DNA replication. Acts as a promoter of sprouting angiogenesis, possibly by acting as a transcription activator: associates with HIF1A, recognizes and binds the VEGFA promoter, which is different from canonical E2 recognition site, and activates expression of the VEGFA gene. Acts as a negative regulator of keratinocyte differentiation..
Immunogen: E2F transcription factor 7
Synonyms:
Reactivity: Human
Tested Application: ELISA, WB, IHC
Recommended dilution:
Image 1: Immunohistochemistry of paraffin-embedded human cervical cancer tissue slide using FNab02603(E2F7 Antibody) at dilution of 1:50
Image 2: .
Image 3:
Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab02603(E2F7 Antibody) at dilution of 1:600
Gene ID: 144455
Research Area: Metabolism
Uniprot ID: Q96AV8
