anti- EIF2AK1 antibody

Product Description

anti- EIF2AK1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Inhibits protein synthesis at the translation initiation level, in response to various stress conditions, including oxidative stress, heme deficiency, osmotic shock and heat shock. Exerts its function through the phosphorylation of EIF2S1 at 'Ser-48' and 'Ser-51', thus preventing its recycling. Binds hemin forming a 1:1 complex through a cysteine thiolate and histidine nitrogenous coordination. This binding occurs with moderate affinity, allowing it to sense the heme concentration within the cell. Thanks to this unique heme-sensing capacity, plays a crucial role to shut off protein synthesis during acute heme-deficient conditions. In red blood cells(RBCs), controls hemoglobin synthesis ensuring a coordinated regulation of the synthesis of its heme and globin moieties. Thus plays an essential protective role for RBC survival in anemias of iron deficiency. Similarly, in hepatocytes, involved in heme-mediated translational control of CYP2B and CYP3A and possibly other hepatic P450 cytochromes. May also contain ER stress during acute heme-deficient conditions(By similarity)..

Immunogen: eukaryotic translation initiation factor 2-alpha kinase 1

Synonyms: EIF2AK1, HCR, HRI, eukaryotic translation initiation factor 2-alpha kinase 1

Reactivity: Human, Mouse

Tested Application: ELISA, WB

Recommended dilution: WB: 1:500 - 1:2000

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Image 4: HL-60 cells were subjected to SDS PAGE followed by western blot with FNab02690(EIF2AK1 antibody) at dilution of 1:1000

Gene ID: 27102

Research Area: Metabolism

Uniprot ID: Q9BQI3