anti- EIF2AK3 antibody

Product Description

anti- EIF2AK3 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Metabolic-stress sensing protein kinase that phosphorylates the alpha subunit of eukaryotic translation initiation factor 2(eIF-2-alpha/EIF2S1) on 'Ser-52' during the unfolded protein response(UPR) and in response to low amino acid availability. Converts phosphorylated eIF-2-alpha/EIF2S1 either in a global protein synthesis inhibitor, leading to a reduced overall utilization of amino acids, or to a translation initiation activator of specific mRNAs, such as the transcriptional activator ATF4, and hence allowing ATF4-mediated reprogramming of amino acid biosynthetic gene expression to alleviate nutrient depletion. Serves as a critical effector of unfolded protein response(UPR)-induced G1 growth arrest due to the loss of cyclin-D1(CCND1). Involved in control of mitochondrial morphology and function..

Immunogen: eukaryotic translation initiation factor 2-alpha kinase 3

Synonyms: PEK, PERK

Reactivity: Human

Tested Application: ELISA, IHC, WB

Recommended dilution:

Image 1:

Image 2: Immunofluorescent analysis of A431 cells using FNab02692(EIF2AK3 Antibody) at dilution of 1:25 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Image 3:

Image 4: Y79 cells were subjected to SDS PAGE followed by western blot with FNab02692(EIF2AK3 antibody) at dilution of 1:500

Gene ID: 9451

Research Area: Metabolism

Uniprot ID: Q9NZJ5