anti- FBXO6 antibody

Product Description

anti- FBXO6 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Substrate-recognition component of some SCF(SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complexes. Involved in endoplasmic reticulum-associated degradation pathway(ERAD) for misfolded lumenal proteins by recognizing and binding sugar chains on unfolded glycoproteins that are retrotranlocated into the cytosol and promoting their ubiquitination and subsequent degradation. Able to recognize and bind denatured glycoproteins, which are modified with not only high-mannose but also complex-type oligosaccharides. Also recognizes sulfated glycans. Also involved in DNA damage response by specifically recognizing activated CHEK1(phosphorylated on 'Ser-345'), promoting its ubiquitination and degradation. Ubiquitination of CHEK1 is required to insure that activated CHEK1 does not accumulate as cells progress through S phase, or when replication forks encounter transient impediments during normal DNA replication..

Immunogen: F-box protein 6

Synonyms: FBG2, FBS2, FBX6

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IHC, WB

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human gliomas using FNab03048(FBXO6 antibody) at dilution of 1:50

Image 2: .

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Image 4: mouse liver tissue were subjected to SDS PAGE followed by western blot with FNab03048(FBXO6 antibody) at dilution of 1:300

Gene ID: 26270

Research Area: Metabolism

Uniprot ID: Q9NRD1