anti- FBXW5 antibody

Product Description

anti- FBXW5 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Substrate recognition component of both SCF(SKP1-CUL1-F-box protein) and DCX(DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B(IL1B) signaling pathway..

Immunogen: F-box and WD repeat domain containing 5

Synonyms: FBW5

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IHC, WB

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human kidney tissue slide using FNab03056(FBXW5 Antibody) at dilution of 1:50

Image 2: .

Image 3:

Image 4: HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab03056(FBXW5 Antibody) at dilution of 1:600

Gene ID: 54461

Research Area: Metabolism

Uniprot ID: Q969U6