anti- FGFR4 antibody

Product Description

anti- FGFR4 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Tyrosine-protein kinase that acts as cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling..

Immunogen: fibroblast growth factor receptor 4

Synonyms: CD334, FGFR 4, FGFR4, JTK2, TKF

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:200-1:1000; IHC: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded human breast cancer tissue slide using FNab03103(FGFR4 Antibody) at dilution of 1:200 heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab03103(FGFR4 antibody) at dilution of 1:400

Gene ID: 2264

Research Area: Metabolism

Uniprot ID: P22455