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Product Description
anti- FLT3 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Tyrosine-protein kinase that acts as cell-surface receptor for the cytokine FLT3LG and regulates differentiation, proliferation and survival of hematopoietic progenitor cells and of dendritic cells. Promotes phosphorylation of SHC1 and AKT1, and activation of the downstream effector MTOR. Promotes activation of RAS signaling and phosphorylation of downstream kinases, including MAPK1/ERK2 and/or MAPK3/ERK1. Promotes phosphorylation of FES, FER, PTPN6/SHP, PTPN11/SHP-2, PLCG1, and STAT5A and/or STAT5B. Activation of wild-type FLT3 causes only marginal activation of STAT5A or STAT5B. Mutations that cause constitutive kinase activity promote cell proliferation and resistance to apoptosis via the activation of multiple signaling pathways..
Immunogen: fms-related tyrosine kinase 3
Synonyms: CD135, FLK2, STK1
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB, IP
Recommended dilution:
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Image 4: mouse brain tissue were subjected to SDS PAGE followed by western blot with FNab03164(FLT3 antibody) at dilution of 1:500
Gene ID: 2322
Research Area: Metabolism
Uniprot ID: P36888
