anti- FOXA2 antibody

Product Description

anti- FOXA2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3'(By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes important for glucose sensing in pancreatic beta-cells and glucose homeostasis. Involved in regulation of fat metabolism. Binds to fibrinogen beta promoter and is involved in IL6-induced fibrinogen beta transcriptional activation..

Immunogen: forkhead box A2

Synonyms: forkhead box A2, Forkhead box protein A2, FOXA2, HNF 3 beta, HNF 3B, HNF3B, TCF 3B, TCF3B, Transcription factor 3B

Reactivity: Human

Tested Application: ELISA, IP, WB, IHC

Recommended dilution: WB: 1:500-1:5000; IP: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded human pancreas tissue slide using FNab03188(FOXA2 Antibody) at dilution of 1:50

Image 2: Immunofluorescent analysis of ( -20? Ethanol ) fixed HepG2 cells using FNab03188 ( FOXA2 Antibody) at dilution of 1:50 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L).

Image 3:

Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab03188(FOXA2 Antibody) at dilution of 1:1000

Gene ID: 3170

Research Area: Metabolism

Uniprot ID: Q9Y261