anti- FOXP3 antibody

Product Description

anti- FOXP3 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Transcriptional regulator which is crucial for the development and inhibitory function of regulatory T-cells(Treg). Plays an essential role in maintaining homeostasis of the immune system by allowing the acquisition of full suppressive function and stability of the Treg lineage, and by directly modulating the expansion and function of conventional T-cells. Can act either as a transcriptional repressor or a transcriptional activator depending on its interactions with other transcription factors, histone acetylases and deacetylases. The suppressive activity of Treg involves the coordinate activation of many genes, including CTLA4 and TNFRSF18 by FOXP3 along with repression of genes encoding cytokines such as interleukin-2(IL2) and interferon-gamma(IFNG). Inhibits cytokine production and T-cell effector function by repressing the activity of two key transcription factors, RELA and NFATC2(PubMed:15790681). Mediates transcriptional repression of IL2 via its association with histone acetylase KAT5 and histone deacetylase HDAC7(PubMed:17360565). Can activate the expression of TNFRSF18, IL2RA and CTLA4 and repress the expression of IL2 and IFNG via its association with transcription factor RUNX1(PubMed:17377532). Inhibits the differentiation of IL17 producing helper T-cells(Th17) by antagonizing RORC function, leading to down-regulation of IL17 expression, favoring Treg development(PubMed:18368049). Inhibits the transcriptional activator activity of RORA(PubMed:18354202). Can repress the expression of IL2 and IFNG via its association with transcription factor IKZF4(By similarity)..

Immunogen: forkhead box P3

Synonyms: AIID, DIETER, forkhead box P3, Forkhead box protein P3, FOXP3, IPEX, JM2, PIDX, Scurfin, XPID

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IP, IHC

Recommended dilution: WB: 1:500-1:5000; IP: 1:500-1:5000; IHC: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded mouse spleen tissue slide using FNab03209(FOXP3 Antibody) at dilution of 1:200. heat mediated antigen retrieved with Tris-EDTA buffer(pH9).

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab03209(FOXP3 antibody) at dilution of 1:2000

Gene ID: 50943

Research Area: Metabolism

Uniprot ID: Q9BZS1