anti- GALE antibody

Product Description

anti- GALE antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: This gene encodes UDP-galactose-4-epimerase which catalyzes two distinct but analogous reactions: the epimerization of UDP-glucose to UDP-galactose, and the epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The bifunctional nature of the enzyme has the important metabolic consequence that mutant cells (or individuals) are dependent not only on exogenous galactose, but also on exogenous N-acetylgalactosamine as a necessary precursor for the synthesis of glycoproteins and glycolipids. Mutations in this gene result in epimerase-deficiency galactosemia, also referred to as galactosemia type 3, a disease characterized by liver damage, early-onset cataracts, deafness and mental retardation, with symptoms ranging from mild ('peripheral' form) to severe ('generalized' form). Multiple alternatively spliced transcripts encoding the same protein have been identified..

Immunogen: UDP-galactose-4-epimerase

Synonyms:

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:200; IF: 1:10 - 1:100

Image 1: Immunohistochemical of paraffin-embedded human malignant melanoma using FNab03309(GALE antibody) at dilution of 1:100

Image 2: Immunofluorescence analysis of A549 cells using FNab03309(GALE antibody) at dilution of 1:50.

Image 3:

Image 4: A375 cells were subjected to SDS PAGE followed by western blot with FNab03309(GALE antibody) at dilution of 1:1000

Gene ID: 2582

Research Area: Metabolism

Uniprot ID: Q14376