anti- GNAI1 antibody

Product Description

anti- GNAI1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Guanine nucleotide-binding proteins(G proteins) function as transducers downstream of G protein-coupled receptors(GPCRs) in numerous signaling cascades. The alpha chain contains the guanine nucleotide binding site and alternates between an active, GTP-bound state and an inactive, GDP-bound state. Signaling by an activated GPCR promotes GDP release and GTP binding. The alpha subunit has a low GTPase activity that converts bound GTP to GDP, thereby terminating the signal. Both GDP release and GTP hydrolysis are modulated by numerous regulatory proteins(PubMed:8774883, PubMed:18434541). Signaling is mediated via effector proteins, such as adenylate cyclase. Inhibits adenylate cyclase activity, leading to decreased intracellular cAMP levels(By similarity). The inactive GDP-bound form prevents the association of RGS14 with centrosomes and is required for the translocation of RGS14 from the cytoplasm to the plasma membrane. Required for normal cytokinesis during mitosis(PubMed:17635935)..

Immunogen: guanine nucleotide binding protein(G protein), alpha inhibiting activity polypeptide 1

Synonyms:

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, FC, IF

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human gliomas using FNab03531(GNAI1 antibody) at dilution of 1:100

Image 2: .

Image 3:

Image 4: human brain tissue were subjected to SDS PAGE followed by western blot with FNab03531(GNAI1 antibody) at dilution of 1:1600

Gene ID: 2770

Research Area: Metabolism

Uniprot ID: P63096