anti- GRK5 antibody

Product Description

anti- GRK5 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors(GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors(more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2(MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin(RHO)(in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling(in vitro)..

Immunogen: G protein-coupled receptor kinase 5

Synonyms: GPRK5

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: human skeletal muscle tissue were subjected to SDS PAGE followed by western blot with FNab0355(GRK5 antibody) at dilution of 1:500

Gene ID: 2869

Research Area: Metabolism

Uniprot ID: P34947