anti- HIC1 antibody

Product Description

anti- HIC1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Transcriptional repressor. Recognizes and binds to the consensus sequence '5-[CG]NG[CG]GGGCA[CA]CC-3'. May act as a tumor suppressor. May be involved in development of head, face, limbs and ventral body wall. Involved in down-regulation of SIRT1 and thereby is involved in regulation of p53/TP53-dependent apoptotic DNA-damage responses. The specific target gene promoter association seems to be depend on corepressors, such as CTBP1 or CTBP2 and MTA1. The regulation of SIRT1 transcription in response to nutrient deprivation seems to involve CTBP1. In cooperation with MTA1(indicative for an association with the NuRD complex) represses transcription from CCND1/cyclin-D1 and CDKN1C/p57Kip2 specifically in quiescent cells. Involved in regulation of the Wnt signaling pathway probably by association with TCF7L2 and preventing TCF7L2 and CTNNB1 association with promoters of TCF-responsive genes. Seems to repress transcription from E2F1 and ATOH1 which involves ARID1A, indicative for the participation of a distinct SWI/SNF-type chromatin-remodeling complex. Probably represses transcription from ACKR3, FGFBP1 and EFNA1..

Immunogen: hypermethylated in cancer 1

Synonyms: ZBTB29

Reactivity: Human, Mouse

Tested Application: ELISA, IHC, WB

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human testis tissue slide using FNab03857(HIC1 Antibody) at dilution of 1:50

Image 2: .

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Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab03857(HIC1 Antibody) at dilution of 1:1000

Gene ID: 3090

Research Area: Metabolism

Uniprot ID: Q14526