anti- IGF1R antibody

Product Description

anti- IGF1R antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: IGF1R, also named as CD221, is a receptor tyrosine kinase which mediates actions of insulin-like growth factor 1 (IGF1). IGF1R binds IGF1 with high affinity and IGF2 and insulin (INS) with a lower affinity, the activated IGF1R is involved in cell growth and survival control. It is crucial for tumor transformation and survival of malignant cell. IGF1R is a heterotetrameric receptor, composed of two alpha subunits (130 kDa each) and two beta subunits (~98 kDa each) (PMID: 6279656). Both the alpha and beta subunits are synthesized from a single mRNA precursor. The precursor is then glycosylated, proteolytically cleaved, and crosslinked by cysteine bonds. .

Immunogen: insulin-like growth factor 1 receptor

Synonyms: CD221, IGFIR, IGFR, JTK13

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human lung cancer tissue slide using FNab04170(IGF1R-Specific antibody) at dilution of 1:100

Image 2: Immunofluorescence analysis of NIH/3T3 cells using FNab04170 (IGF1R-Specific antibody) at dilution of 1:100. Blue: DAPI for nuclear staining..

Image 3:

Image 4: MCF7 cells were subjected to SDS PAGE followed by western blot with FNab04170(IGF1R-Specific antibody) at dilution of 1:1000

Gene ID: 3480

Research Area: Metabolism

Uniprot ID: P08069