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Product Description
anti- IL-17 antibody is available at Gentaur for Next week Delivery.
Purification: Protein A+G purification
Background: IL17A, also named as IL-17, is a proinflammatory cytokine. IL-17, synthesized only by memory T cells and natural killer cells, has pleiotropic effects, mainly in the recruitment and activation of neutrophils. This cytokine regulates the activities of NF-kappaB and mitogen-activated protein kinases. This cytokine can stimulate the expression of IL6 and cyclooxygenase-2(PTGS2/COX-2), as well as enhance the production of nitric oxide(NO). High levels of this cytokine are associated with several chronic inflammatory diseases including rheumatoid arthritis, psoriasis and multiple sclerosis. The IL-17 receptor is a type I transmembrane protein, that is widely expressed on epithelial cells, fibroblasts, B and T cells, and monocytic cells. In psoriatic skin lesions, both Th17 cells and their downstream effector molecules, e.g. IL-17 and IL-22, are highly increased..
Immunogen: interleukin 17A
Synonyms: CTLA 8, CTLA8, IL 17, IL 17A, IL17, IL-17, IL17A, interleukin 17A
Reactivity: Human
Tested Application: ELISA, WB, FC
Recommended dilution: WB: 1:500-1:1000
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Image 4: U-937 cells were subjected to SDS PAGE followed by western blot with FNab04225(IL-17 antibody) at dilution of 1:500
Gene ID: 3605
Research Area: Metabolism
Uniprot ID: Q16552
