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Product Description
anti- IL33 antibody is available at Gentaur for Next week Delivery.
Purification: Protein A+G purification
Background: Cytokine that binds to and signals through the IL1RL1/ST2 receptor which in turn activates NF-kappa-B and MAPK signaling pathways in target cells(PubMed:16286016). Involved in the maturation of Th2 cells inducing the secretion of T-helper type 2-associated cytokines. Also involved in activation of mast cells, basophils, eosinophils and natural killer cells. Acts as a chemoattractant for Th2 cells, and may function as an "alarmin", that amplifies immune responses during tissue injury(PubMed:17853410, PubMed:18836528). In quiescent endothelia the uncleaved form is constitutively and abundantly expressed, and acts as a chromatin-associated nuclear factor with transcriptional repressor properties, it may sequester nuclear NF-kappaB/RELA, lowering expression of its targets(PubMed:21734074). This form is rapidely lost upon angiogenic or proinflammatory activation(PubMed:18787100)..
Immunogen: interleukin 33
Synonyms: C9orf26, IL1F11, NFHEV
Reactivity: Human
Tested Application: ELISA, IHC, WB
Recommended dilution: WB: 1:500-1:2000; IHC: 1:50-1:500
Image 1: Immunohistochemistry of paraffin-embedded human nasopharyngeal carcinoma tissue slide using FNab04272(IL33 Antibody) at dilution of 1:200
Image 2: .
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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab04272(IL33 Antibody) at dilution of 1:1000
Gene ID: 90865
Research Area: Metabolism
Uniprot ID: O95760
