anti- ISCU antibody

Product Description

anti- ISCU antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Scaffold protein for the de novo synthesis of iron-sulfur(Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins(PubMed:11060020). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISCU depends on the function of the cysteine desulfurase complex NFS1-LYRM4/ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH(By similarity)..

Immunogen: iron-sulfur cluster scaffold homolog(E. coli)

Synonyms: NIFUN

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF, IP

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human lung cancer using FNab04402(ISCU antibody) at dilution of 1:50

Image 2: .

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Image 4: mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab04402(ISCU antibody) at dilution of 1:500

Gene ID: 23479

Research Area: Metabolism

Uniprot ID: Q9H1K1