anti- JAML antibody

Product Description

anti- JAML antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Transmembrane protein of the plasma membrane of leukocytes that control their migration and activation through interaction with CXADR, a plasma membrane receptor found on adjacent epithelial and endothelial cells. The interaction between both receptors mediates the activation of gamma-delta T-cells, a subpopulation of T-cells residing in epithelia and involved in tissue homeostasis and repair. Upon epithelial CXADR-binding, JAML induces downstream cell signaling events in gamma-delta T-cells through PI3-kinase and MAP kinases. It results in proliferation and production of cytokines and growth factors by T-cells that in turn stimulate epithelial tissues repair. It also controls the transmigration of leukocytes within epithelial and endothelial tissues through adhesive interactions with epithelial and endothelial CXADR..

Immunogen: adhesion molecule, interacts with CXADR antigen 1

Synonyms: AMICA1

Reactivity: Human

Tested Application: ELISA, WB, IHC, IF, FC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human spleen using FNab04436(AMICA1 antibody) at dilution of 1:100

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Image 4: HL-60 cells were subjected to SDS PAGE followed by western blot with FNab04436(AMICA1 antibody) at dilution of 1:800

Gene ID: 120425

Research Area: Metabolism

Uniprot ID: Q86YT9