anti- JMY antibody

Product Description

anti- JMY antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Acts both as a nuclear p53/TP53-cofactor and a cytoplasmic regulator of actin dynamics depending on conditions. In nucleus, acts as a cofactor that increases p53/TP53 response via its interaction with p300/EP300. Increases p53/TP53-dependent transcription and apoptosis, suggesting an important role in p53/TP53 stress response such as DNA damage. In cytoplasm, acts as a nucleation-promoting factor for both branched and unbranched actin filaments. Activates the Arp2/3 complex to induce branched actin filament networks. Also catalyzes actin polymerization in the absence of Arp2/3, creating unbranched filaments. Contributes to cell motility by controlling actin dynamics. May promote the rapid formation of a branched actin network by first nucleating new mother filaments and then activating Arp2/3 to branch off these filaments. The p53/TP53-cofactor and actin activator activities are regulated via its subcellular location(By similarity)..

Immunogen: junction mediating and regulatory protein, p53 cofactor

Synonyms: JMY, WHDC1L3

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500-1:2000; IHC: 1:20-1:200; IF: 1:10-1:100

Image 1: Immunohistochemistry of paraffin-embedded human colon cancer tissue slide using FNab04443(JMY Antibody) at dilution of 1:50

Image 2: Immunofluorescent analysis of HeLa cells using FNab04443 (JMY antibody) at dilution of 1:25 and Rhodamine-Goat anti-Rabbit IgG.

Image 3:

Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab04443(JMY Antibody) at dilution of 1:1000

Gene ID: 133746

Research Area: Metabolism

Uniprot ID: Q8N9B5