anti- KIF7 antibody

Product Description

anti- KIF7 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Essential for hedgehog signaling regulation: acts as both a negative and positive regulator of sonic hedgehog(Shh) and Indian hedgehog(Ihh) pathways, acting downstream of SMO, through both SUFU-dependent and-independent mechanisms(PubMed:21633164). Involved in the regulation of microtubular dynamics. Required for proper organization of the ciliary tip and control of ciliary localization of SUFU-GLI2 complexes(By similarity). Required for localization of GLI3 to cilia in response to Shh. Negatively regulates Shh signaling by preventing inappropriate activation of the transcriptional activator GLI2 in the absence of ligand. Positively regulates Shh signaling by preventing the processing of the transcription factor GLI3 into its repressor form. In keratinocytes, promotes the dissociation of SUFU-GLI2 complexes, GLI2 nuclear translocation and Shh signaling activation(By similarity). Involved in the regulation of epidermal differentiation and chondrocyte development(By similarity)..

Immunogen: kinesin family member 7

Synonyms: KIF7, kinesin family member 7, Kinesin like protein KIF7, UNQ340

Reactivity: Human

Tested Application: ELISA, IP, WB

Recommended dilution: WB: 1:500-1:2000; IP: 1:500-1:1000

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Image 2: .

Image 3: IP Result of anti-KIF7 (IP: FNab04570, 4ug; Detection: FNab04570 1:500) with HEK-293 cells lysate 2000ug.

Image 4: HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab04570( KIF7 Antibody) at dilution of 1:1000

Gene ID: 374654

Research Area: Metabolism

Uniprot ID: Q2M1P5