anti- LARGE antibody

Product Description

anti- LARGE antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Bifunctional glycosyltransferase with both xylosyltransferase and beta-1,3-glucuronyltransferase activities involved in the biosynthesis of the phosphorylated O-mannosyl trisaccharide(N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4-(phosphate-6-)mannose), a carbohydrate structure present in alpha-dystroglycan(DAG1)(PubMed:22223806). Phosphorylated O-mannosyl trisaccharid is required for binding laminin G-like domain-containing extracellular proteins with high affinity and plays a key role in skeletal muscle function and regeneration. LARGE elongates the glucuronyl-beta-1,4-xylose-beta disaccharide primer structure initiated by B3GNT1/B4GAT1 by adding repeating units [-3-Xylose-alpha-1,3-GlcA-beta-1-] to produce a heteropolysaccharide(PubMed:25279699)..

Immunogen: like-glycosyltransferase

Synonyms: KIAA0609, LARGE1

Reactivity: Human, Mouse

Tested Application: ELISA, WB

Recommended dilution:

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Image 4: mouse kidney tissue were subjected to SDS PAGE followed by western blot with FNab04697( LARGE Antibody) at dilution of 1:1000

Gene ID: 9215

Research Area: Metabolism

Uniprot ID: O95461