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Product Description
anti- METAP2 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged(Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). The catalytic activity of human METAP2 toward Met-Val peptides is consistently two orders of magnitude higher than that of METAP1, suggesting that it is responsible for processing proteins containing N-terminal Met-Val and Met-Thr sequences in vivo. Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis..
Immunogen: methionyl aminopeptidase 2
Synonyms: MNPEP, P67EIF2
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB, IHC
Recommended dilution:
Image 1: Immunohistochemistry of paraffin-embedded human testis using FNab05135(METAP2 antibody) at dilution of 1:50
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Image 4: HepG2 cells were subjected to SDS PAGE followed by western blot with FNab05135(METAP2 antibody) at dilution of 1:300
Gene ID: 10988
Research Area: Metabolism
Uniprot ID: P50579
