anti- MLXIP antibody

Product Description

anti- MLXIP antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Mlx-interacting protein(MLXIP), after forming heterodimers with MLX, can bind to and then activate transcription from CACGTG E boxes. The N terminus of MLXIP acts as a CRM1-dependent nuclear export signal and contribute to the cytoplasmic localization of the complex, and as a binding site for 13 protein. the C terminus contains a cytoplasmic localization signal and mediates protein-protein interaction of MONDOA and MLX. The complex play a role in transcriptional activation of glycolytic target genes and glucose-responsive gene regulation. This antibody could recognize isoform1(~110kd) and isoform3(~69kd) of MLXIP. A specific MLXIP of approximately 130 kDa was detected. It demonstrates that MLXIP associated specifically with Mlx in the cytoplasm (PMID: 11073985)..

Immunogen: MLX interacting protein

Synonyms: BHLHE36, KIAA0867, MIR, MONDOA

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:200-1:1000; IHC: 1:20-1:200; IF: 1:10-1:100

Image 1: Immunohistochemistry of paraffin-embedded human skeletal muscle using FNab05223(MLXIP antibody) at dilution of 1:100

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Image 4: K-562 cells were subjected to SDS PAGE followed by western blot with FNab05223(MLXIP antibody) at dilution of 1:500

Gene ID: 22877

Research Area: Metabolism

Uniprot ID: Q9HAP2