anti- MMS19 antibody

Product Description

anti- MMS19 antibody is available at Gentaur for Next week Delivery.

Purification: Protein A+G purification

Background: Key component of the cytosolic iron-sulfur protein assembly(CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins such as ERCC2/XPD, FANCJ and RTEL1, thereby playing a key role in nucleotide excision repair(NER) and RNA polymerase II(POL II) transcription. As part of the mitotic spindle-associated MMXD complex, plays a role in chromosome segregation, probably by facilitating iron-sulfur cluster assembly into ERCC2/XPD. Indirectly acts as a transcriptional coactivator of estrogen receptor(ER), via its role in iron-sulfur insertion into some component of the TFIIH-machinery..

Immunogen: MMS19 nucleotide excision repair homolog(S. cerevisiae)

Synonyms: MMS19L

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IF, IHC

Recommended dilution: WB: 1:1000-1:4000; IHC: 1:20-1:200; IF: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human cervical cancer using FNab05249(MMS19 antibody) at dilution of 1:50

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab05249( MMS19 Antibody) at dilution of 1:2000

Gene ID: 64210

Research Area: Metabolism

Uniprot ID: Q96T76