anti- MYLK antibody

Product Description

anti- MYLK antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: This gene, a muscle member of the immunoglobulin gene superfamily, encodes myosin light chain kinase which is a calcium/calmodulin dependent enzyme. This kinase phosphorylates myosin regulatory light chains to facilitate myosin interaction with actin filaments to produce contractile activity. This gene encodes both smooth muscle and nonmuscle isoforms. In addition, using a separate promoter in an intron in the 3' region, it encodes telokin, a small protein identical in sequence to the C-terminus of myosin light chain kinase, that is independently expressed in smooth muscle and functions to stabilize unphosphorylated myosin filaments. A pseudogene is located on the p arm of chromosome 3. Four transcript variants that produce four isoforms of the calcium/calmodulin dependent enzyme have been identified as well as two transcripts that produce two isoforms of telokin. Additional variants have been identified but lack full length transcripts..

Immunogen: myosin light chain kinase

Synonyms: MLCK, MLCK1, MYLK1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution: WB: 1:500 - 1:2000; IHC: 1:50 - 1:100

Image 1: Immunohistochemistry of paraffin-embedded mouse kidney using FNab05493(MYLK antibody) at dilution of 1:100

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Image 4: HeLa cells were subjected to SDS PAGE followed by western blot with FNab05493(MYLK antibody) at dilution of 1:1000

Gene ID: 4638

Research Area: Metabolism

Uniprot ID: Q15746