anti- NHLRC1 antibody

Product Description

anti- NHLRC1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: E3 ubiquitin-protein ligase. Together with the phosphatase EPM2A/laforin, appears to be involved in the clearance of toxic polyglucosan and protein aggregates via multiple pathways. In complex with EPM2A/laforin and HSP70, suppresses the cellular toxicity of misfolded proteins by promoting their degradation through the ubiquitin-proteasome system(UPS). Ubiquitinates the glycogen-targeting protein phosphatase subunits PPP1R3C/PTG and PPP1R3D in a laforin-dependent manner and targets them for proteasome-dependent degradation, thus decreasing glycogen accumulation. Polyubiquitinates EPM2A/laforin and ubiquitinates AGL and targets them for proteasome-dependent degradation. Also promotes proteasome-independent protein degradation through the macroautophagy pathway..

Immunogen: NHL repeat containing 1

Synonyms: EPM2B

Reactivity: Human

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human heart using FNab05726(NHLRC1 antibody) at dilution of 1:50

Image 2: .

Image 3:

Image 4: L02 cells were subjected to SDS PAGE followed by western blot with FNab05726(NHLRC1 antibody) at dilution of 1:400

Gene ID: 378884

Research Area: Metabolism

Uniprot ID: Q6VVB1