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Product Description
anti- NLRP1 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: As the sensor component of the NLRP1 inflammasome, plays a crucial role in innate immunity and inflammation. In response to pathogens and other damage-associated signals, initiates the formation of the inflammasome polymeric complex, made of NLRP1, CASP1, and possibly PYCARD. Recruitment of proCASP1 to the inflammasome promotes its activation and CASP1-catalyzed IL1B and IL18 maturation and secretion in the extracellular milieu. Activation of NLRP1 inflammasome is also required for HMGB1 secretion. The active cytokines and HMGB1 stimulate inflammatory responses. Inflammasomes can also induce pyroptosis, an inflammatory form of programmed cell death(PubMed:22665479, PubMed:17418785). May be activated by muramyl dipeptide(MDP), a fragment of bacterial peptidoglycan, in a NOD2-dependent manner(PubMed:18511561). Contrary to its mouse ortholog, not activated by Bacillus anthracis lethal toxin(PubMed:19651869). It is unclear whether isoform 2 is involved in inflammasome formation. It is not cleaved within the FIIND domain, does not assemble into specks, nor promote IL1B release(PubMed:22665479). However, in an vitro cell-free system, it has been shown to be activated by MDP(PubMed:17349957). Binds ATP(PubMed:11113115, PubMed:15212762)..
Immunogen: NLR family, pyrin domain containing 1
Synonyms: CARD7, CLR17.1, DEFCAP, DEFCAP L/S, DKFZp586O1822, KIAA0926, NAC, NALP1, NLRP1, PP1044, SLEV1, VAMAS1
Reactivity: Human
Tested Application: ELISA, IHC, WB
Recommended dilution: WB: 1:500-1:2000; IHC: 1:20-1:200
Image 1: Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab05757(NLRP1 antibody) at dilution of 1:50
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Image 4: Transfected HEK-293 cells were subjected to SDS PAGE followed by western blot with FNab05757(NLRP1 Antibody) at dilution of 1:1000
Gene ID: 22861
Research Area: Metabolism
Uniprot ID: Q9C000
