anti- NR5A1 antibody

Product Description

anti- NR5A1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Transcriptional activator. Seems to be essential for sexual differentiation and formation of the primary steroidogenic tissues. Binds to the Ad4 site found in the promoter region of steroidogenic P450 genes such as CYP11A, CYP11B and CYP21B. Also regulates the AMH/Muellerian inhibiting substance gene as well as the AHCH and STAR genes. 5'-YCAAGGYC-3' and 5'-RRAGGTCA-3' are the consensus sequences for the recognition by NR5A1. The SFPQ-NONO-NR5A1 complex binds to the CYP17 promoter and regulates basal and cAMP-dependent transcriptional avtivity. Binds phosphatidylcholine(By similarity). Binds phospholipids with a phosphatidylinositol(PI) headgroup, in particular PI(3,4)P2 and PI(3,4,5)P3. Activated by the phosphorylation of NR5A1 by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation..

Immunogen: nuclear receptor subfamily 5, group A, member 1

Synonyms: AD4BP, FTZF1, SF1

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IP

Recommended dilution: WB: 1:500-1:5000; IP: 1:200-1:1000; IHC: 1:20-1:200

Image 1: Immunohistochemistry of paraffin-embedded human liver using FNab05847(NR5A1 antibody) at dilution of 1:100

Image 2: .

Image 3: IP Result of anti-NR5A1 (IP: FNab05847, 4ug; Detection: FNab05847 1:300) with A2780 cells lysate 960ug.

Image 4: mouse ovary tissue were subjected to SDS PAGE followed by western blot with FNab05847(NR5A1 antibody) at dilution of 1:1000

Gene ID: 2516

Research Area: Metabolism

Uniprot ID: Q13285