anti- NRG1 antibody

Product Description

anti- NRG1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Direct ligand for ERBB3 and ERBB4 tyrosine kinase receptors. Concomitantly recruits ERBB1 and ERBB2 coreceptors, resulting in ligand-stimulated tyrosine phosphorylation and activation of the ERBB receptors. The multiple isoforms perform diverse functions such as inducing growth and differentiation of epithelial, glial, neuronal, and skeletal muscle cells; inducing expression of acetylcholine receptor in synaptic vesicles during the formation of the neuromuscular junction; stimulating lobuloalveolar budding and milk production in the mammary gland and inducing differentiation of mammary tumor cells; stimulating Schwann cell proliferation; implication in the development of the myocardium such as trabeculation of the developing heart. Isoform 10 may play a role in motor and sensory neuron development. Binds to ERBB4(PubMed:10867024, PubMed:7902537). Binds to ERBB3(PubMed:20682778). Acts as a ligand for integrins and binds(via EGF domain) to integrins ITGAV:ITGB3 or ITGA6:ITGB4. Its binding to integrins and subsequent ternary complex formation with integrins and ERRB3 are essential for NRG1-ERBB signaling. Induces the phosphorylation and activation of MAPK3/ERK1, MAPK1/ERK2 and AKT1(PubMed:20682778). Ligand-dependent ERBB4 endocytosis is essential for the NRG1-mediated activation of these kinases in neurons(By similarity)..

Immunogen: neuregulin 1

Synonyms: GGF, HGL, HRGA, NDF, SMDF

Reactivity: Human, Mouse

Tested Application: ELISA, WB, IHC, IF, IP

Recommended dilution: WB: 1:500-1:1000; IHC: 1:50-1:200 IP:1:500-1:2000; IF: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded human breast cancer using FNab05856(NRG1 antibody) at dilution of 1:100

Image 2: Immunofluorescent analysis of HepG2 cells using FNab05856 (NRG1 antibody) at dilution of 1:25 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L).

Image 3:

Image 4: human liver tissue were subjected to SDS PAGE followed by western blot with FNab05856(NRG1 antibody) at dilution of 1:250

Gene ID: 3084

Research Area: Metabolism

Uniprot ID: Q02297