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Product Description
anti- NUMBL antibody is available at Gentaur for Next week Delivery.
Purification: Protein A+G purification
Background: Plays a role in the process of neurogenesis. Required throughout embryonic neurogenesis to maintain neural progenitor cells, also called radial glial cells(RGCs), by allowing their daughter cells to choose progenitor over neuronal cell fate. Not required for the proliferation of neural progenitor cells before the onset of embryonic neurogenesis. Also required postnatally in the subventricular zone(SVZ) neurogenesis by regulating SVZ neuroblasts survival and ependymal wall integrity. Negative regulator of NF-kappa-B signaling pathway. The inhibition of NF-kappa-B activation is mediated at least in part, by preventing MAP3K7IP2 to interact with polyubiquitin chains of TRAF6 and RIPK1 and by stimulating the 'Lys-48'-linked polyubiquitination and degradation of TRAF6 in cortical neurons..
Immunogen: numb homolog(Drosophila)-like
Synonyms:
Reactivity: Human
Tested Application: ELISA, WB, IHC
Recommended dilution: WB: 1:500-1:2000; IHC: 1:20-1:200
Image 1: Immunohistochemistry of paraffin-embedded human gliomas tissue slide using FNab05918(NUMBLIKE Antibody) at dilution of 1:50
Image 2: .
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Image 4: L02 cells were subjected to SDS PAGE followed by western blot with FNab05918(NUMBLIKE Antibody) at dilution of 1:1000
Gene ID: 9253
Research Area: Metabolism
Uniprot ID: Q9Y6R0
