anti- PADI4 antibody

Product Description

anti- PADI4 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Catalyzes the citrullination/deimination of arginine residues of proteins such as histones, thereby playing a key role in histone code and regulation of stem cell maintenance. Citrullinates histone H1 at 'Arg-54'(to form H1R54ci), histone H3 at 'Arg-2', 'Arg-8', 'Arg-17' and/or 'Arg-26'(to form H3R2ci, H3R8ci, H3R17ci, H3R26ci, respectively) and histone H4 at 'Arg-3'(to form H4R3ci). Acts as a key regulator of stem cell maintenance by mediating citrullination of histone H1: citrullination of 'Arg-54' of histone H1(H1R54ci) results in H1 displacement from chromatin and global chromatin decondensation, thereby promoting pluripotency and stem cell maintenance. Promotes profound chromatin decondensation during the innate immune response to infection in neutrophils by mediating formation of H1R54ci. Citrullination of histone H3 prevents their methylation by CARM1 and HRMT1L2/PRMT1 and represses transcription. Citrullinates EP300/P300 at 'Arg-2142', which favors its interaction with NCOA2/GRIP1..

Immunogen: peptidyl arginine deiminase, type IV

Synonyms: PAD4, PADI5, PDI5

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution: WB: 1:500-1:2000; IHC: 1:100-1:500; IF: 1:10-1:100

Image 1: Immunohistochemistry of paraffin-embedded human tonsillitis tissue slide using FNab06105(PADI4 Antibody) at dilution of 1:200

Image 2: Immunofluorescent analysis of A549 cells using FNab06105 (PADI4 antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L).

Image 3:

Image 4: BT474 cells were subjected to SDS PAGE followed by western blot with FNab06105(PADI4 Antibody) at dilution of 1:600

Gene ID: 23569

Research Area: Metabolism

Uniprot ID: Q9UM07