anti- PAN2 antibody

Product Description

anti- PAN2 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Catalytic subunit of the poly(A)-nuclease(PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA when the poly(A) stretch is bound by poly(A)-binding protein(PABP), which is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1..

Immunogen: PAN2 poly(A) specific ribonuclease subunit homolog(S. cerevisiae)

Synonyms: KIAA0710, USP52

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human heart using FNab06131(PAN2 antibody) at dilution of 1:50

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Image 4: NIH/3T3 cells were subjected to SDS PAGE followed by western blot with FNab06131(PAN2 antibody) at dilution of 1:300

Gene ID: 9924

Research Area: Metabolism

Uniprot ID: Q504Q3