anti- PDE9A antibody

Product Description

anti- PDE9A antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP(PubMed:9624146, PubMed:18757755, PubMed:21483814). Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart(PubMed:25799991). Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein(Probable). In brain, involved in cognitive function, such as learning and long-term memory(By similarity)..

Immunogen: phosphodiesterase 9A

Synonyms: HSPDE9A2, PDE9A, phosphodiesterase 9A

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, IF, IHC

Recommended dilution: IHC: 1:100-1:200; IF: 1:50-1:500

Image 1: Immunohistochemistry of paraffin-embedded human prostate cancer tissue slide using FNab06263(PDE9A Antibody) at dilution of 1:200

Image 2: Immunofluorescent analysis of ( -20? Ethanol ) fixed A549 cells using FNab06263 (PDE9A antibody) at dilution of 1:50 and Alexa Fluor 488-conjugated Goat Anti-Rabbit IgG(H+L).

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Gene ID: 5152

Research Area: Metabolism

Uniprot ID: O76083