anti- PDK4 antibody

Product Description

anti- PDK4 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Kinase that plays a key role in regulation of glucose and fatty acid metabolism and homeostasis via phosphorylation of the pyruvate dehydrogenase subunits PDHA1 and PDHA2. This inhibits pyruvate dehydrogenase activity, and thereby regulates metabolite flux through the tricarboxylic acid cycle, down-regulates aerobic respiration and inhibits the formation of acetyl-coenzyme A from pyruvate. Inhibition of pyruvate dehydrogenase decreases glucose utilization and increases fat metabolism in response to prolonged fasting and starvation. Plays an important role in maintaining normal blood glucose levels under starvation, and is involved in the insulin signaling cascade. Via its regulation of pyruvate dehydrogenase activity, plays an important role in maintaining normal blood pH and in preventing the accumulation of ketone bodies under starvation. In the fed state, mediates cellular responses to glucose levels and to a high-fat diet. Regulates both fatty acid oxidation and de novo fatty acid biosynthesis. Plays a role in the generation of reactive oxygen species. Protects detached epithelial cells against anoikis. Plays a role in cell proliferation via its role in regulating carbohydrate and fatty acid metabolism..

Immunogen: pyruvate dehydrogenase kinase, isozyme 4

Synonyms: PDHK4

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human kidney using FNab06279(PDK4 antibody) at dilution of 1:50

Image 2: .

Image 3:

Image 4: mouse heart tissue were subjected to SDS PAGE followed by western blot with FNab06279(PDK4 antibody) at dilution of 1:1000

Gene ID: 5166

Research Area: Metabolism

Uniprot ID: Q16654