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Product Description
anti- PIAS4 antibody is available at Gentaur for Next week Delivery.
Purification: Immunogen affinity purified
Background: Functions as an E3-type small ubiquitin-like modifier(SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations. Enhances the sumoylation of MTA1 and may participate in its paralog-selective sumoylation..
Immunogen: protein inhibitor of activated STAT, 4
Synonyms: E3 SUMO protein ligase PIAS4, PIAS gamma, PIAS4, Piasg, PIASY, ZMIZ6
Reactivity: Human, Mouse, Rat
Tested Application: ELISA, WB, IF
Recommended dilution: WB: 1:500-1:2000; IF: 1:50-1:500
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Image 4: Jurkat cells were subjected to SDS PAGE followed by western blot with FNab6432(PIAS4 antibody) at dilution of 1:500
Gene ID: 51588
Research Area: Metabolism
Uniprot ID: Q8N2W9
