anti- PMEPA1 antibody

Product Description

anti- PMEPA1 antibody is available at Gentaur for Next week Delivery.

Purification: Immunogen affinity purified

Background: Functions as a negative regulator of TGF-beta signaling and thereby probably plays a role in cell proliferation, differentiation, apoptosis, motility, extracellular matrix production and immunosuppression. In the canonical TGF-beta pathway, ZFYVE9/SARA recruits the intracellular signal transducer and transcriptional modulators SMAD2 and SMAD3 to the TGF-beta receptor. Phosphorylated by the receptor, SMAD2 and SMAD3 then form a heteromeric complex with SMAD4 that translocates to the nucleus to regulate transcription. Through interaction with SMAD2 and SMAD3, LDLRAD4 may compete with ZFYVE9 and SMAD4 and prevent propagation of the intracellular signal(PubMed:20129061, PubMed:24627487). Also involved in down-regulation of the androgen receptor(AR), enhancing ubiquitination and proteasome-mediated degradation of AR, probably by recruiting NEDD4(PubMed:18703514)..

Immunogen: prostate transmembrane protein, androgen induced 1

Synonyms: STAG1, TMEPAI

Reactivity: Human, Mouse, Rat

Tested Application: ELISA, WB, IHC, IF

Recommended dilution:

Image 1: Immunohistochemistry of paraffin-embedded human prostate cancer using FNab06569(PMEPA1 antibody) at dilution of 1:50

Image 2: .

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Image 4: L02 cells were subjected to SDS PAGE followed by western blot with FNab06569(PMEPA1 Antibody) at dilution of 1:600

Gene ID: 56937

Research Area: Metabolism

Uniprot ID: Q969W9